MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils

The mammalian antibody repertoire is shaped by somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin (Ig) loci of B lymphocytes. SHM and CSR are triggered by non-canonical, error-prone processing of G/U mismatches generated by activation-induced deaminase (AID). In b...

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Detalles Bibliográficos
Autores principales: Campo, Vanina A., Patenaude, Anne-Marie, Kaden, Svenja, Horb, Lori, Firka, Daniel, Jiricny, Josef, Di Noia, Javier M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597665/
https://www.ncbi.nlm.nih.gov/pubmed/23314153
http://dx.doi.org/10.1093/nar/gks1470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597665/
https://www.ncbi.nlm.nih.gov/pubmed/23314153
http://dx.doi.org/10.1093/nar/gks1470

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