Cargando…

MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils

The mammalian antibody repertoire is shaped by somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin (Ig) loci of B lymphocytes. SHM and CSR are triggered by non-canonical, error-prone processing of G/U mismatches generated by activation-induced deaminase (AID). In b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Campo, Vanina A., Patenaude, Anne-Marie, Kaden, Svenja, Horb, Lori, Firka, Daniel, Jiricny, Josef, Di Noia, Javier M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597665/ https://www.ncbi.nlm.nih.gov/pubmed/23314153 http://dx.doi.org/10.1093/nar/gks1470

Ejemplares similares

Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination
por: Bregenhorn, Stephanie, et al.
Publicado: (2016)

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung(−/−)Msh2(−/−) mice
por: Kemmerich, Kristin, et al.
Publicado: (2012)

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
por: Sarno, Antonio, et al.
Publicado: (2019)

RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork
por: Kavli, Bodil, et al.
Publicado: (2021)

N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA–dsDNA junctions
por: Weiser, Brian P, et al.
Publicado: (2018)

Handcuffing intrinsically disordered regions in Mlh1–Pms1 disrupts mismatch repair
por: Furman, Christopher M, et al.
Publicado: (2021)

Coordination of Rad1–Rad10 interactions with Msh2–Msh3, Saw1 and RPA is essential for functional 3′ non-homologous tail removal
por: Eichmiller, Robin, et al.
Publicado: (2018)

MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1
por: Oh, Jung-Min, et al.
Publicado: (2023)

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA
por: Eldin, Patrick, et al.
Publicado: (2014)

Excision of uracil from DNA by hSMUG1 includes strand incision and processing
por: Alexeeva, Marina, et al.
Publicado: (2019)

Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1
por: Bregenhorn, Stephanie, et al.
Publicado: (2014)

DNA uracil repair initiated by the archaeal ExoIII homologue Mth212 via direct strand incision
por: Schomacher, Lars, et al.
Publicado: (2009)

Analysis of the impact of a uracil DNA glycosylase attenuated in AP-DNA binding in maintenance of the genomic integrity in Escherichia coli
por: Bharti, Sanjay Kumar, et al.
Publicado: (2010)

Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity
por: Chembazhi, Ullas Valiya, et al.
Publicado: (2017)

Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair
por: Shahi, Ankita, et al.
Publicado: (2011)

Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation
por: Lv, Lingna, et al.
Publicado: (2013)

MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions
por: Keogh, Norma, et al.
Publicado: (2017)

Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase
por: Roberts, Victoria A., et al.
Publicado: (2012)

Synthetic lethality between BRCA1 deficiency and poly(ADP-ribose) polymerase inhibition is modulated by processing of endogenous oxidative DNA damage
por: Giovannini, Sara, et al.
Publicado: (2019)

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
por: Talhaoui, Ibtissam, et al.
Publicado: (2013)

ATAD5 deficiency alters DNA damage metabolism and sensitizes cells to PARP inhibition
por: Giovannini, Sara, et al.
Publicado: (2020)

Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway
por: Grippon, Seden, et al.
Publicado: (2011)

XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility
por: McNeill, Daniel R., et al.
Publicado: (2011)

A double-strand break can trigger immunoglobulin gene conversion
por: Bastianello, Giulia, et al.
Publicado: (2017)

The role of G-density in switch region repeats for immunoglobulin class switch recombination
por: Zhang, Zheng Z., et al.
Publicado: (2014)

Ubc13 dosage is critical for immunoglobulin gene conversion and gene targeting in vertebrate cells
por: Ertongur, Isin, et al.
Publicado: (2010)

Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair
por: Hermans, Nicolaas, et al.
Publicado: (2016)

Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases
por: Rajendra, Eeson, et al.
Publicado: (2014)

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma
por: Saha, Janapriya, et al.
Publicado: (2021)

DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP
por: Mimmler, Maximilian, et al.
Publicado: (2016)

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation
por: Williamson, Elizabeth A., et al.
Publicado: (2008)

Metnase promotes restart and repair of stalled and collapsed replication forks
por: De Haro, Leyma P., et al.
Publicado: (2010)

The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
por: Safavi, Shiva, et al.
Publicado: (2020)

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
por: Sabouri, Nasim, et al.
Publicado: (2008)

Viral AlkB proteins repair RNA damage by oxidative demethylation
por: van den Born, Erwin, et al.
Publicado: (2008)

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts
por: Labit, Hélène, et al.
Publicado: (2008)

Editing of misaligned 3′-termini by an intrinsic 3′–5′ exonuclease activity residing in the PHP domain of a family X DNA polymerase
por: Baños, Benito, et al.
Publicado: (2008)

Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots
por: Liapis, Evagelos, et al.
Publicado: (2008)

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
por: Jayaram, Sumithra, et al.
Publicado: (2008)

The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase δ
por: Selak, Nives, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_n6q1ds74rcjpnri55ikckc8ho8