A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks

Trans-lesion DNA synthesis (TLS) is a DNA damage-tolerance mechanism that uses low-fidelity DNA polymerases to replicate damaged DNA. The inherited cancer-propensity syndrome xeroderma pigmentosum variant (XPV) results from error-prone TLS of UV-damaged DNA. TLS is initiated when the Rad6/Rad18 comp...

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Detalles Bibliográficos
Autores principales: Durando, Michael, Tateishi, Satoshi, Vaziri, Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597682/
https://www.ncbi.nlm.nih.gov/pubmed/23345618
http://dx.doi.org/10.1093/nar/gkt016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597682/
https://www.ncbi.nlm.nih.gov/pubmed/23345618
http://dx.doi.org/10.1093/nar/gkt016

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