RNase H2 roles in genome integrity revealed by unlinking its activities

Ribonuclease H2 (RNase H2) protects genome integrity by its dual roles of resolving transcription-related R-loops and ribonucleotides incorporated in DNA during replication. To unlink these two functions, we generated a Saccharomyces cerevisiae RNase H2 mutant that can resolve R-loops but cannot cle...

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Detalles Bibliográficos
Autores principales: Chon, Hyongi, Sparks, Justin L., Rychlik, Monika, Nowotny, Marcin, Burgers, Peter M., Crouch, Robert J., Cerritelli, Susana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597693/
https://www.ncbi.nlm.nih.gov/pubmed/23355612
http://dx.doi.org/10.1093/nar/gkt027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597693/
https://www.ncbi.nlm.nih.gov/pubmed/23355612
http://dx.doi.org/10.1093/nar/gkt027

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