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RNase H2 roles in genome integrity revealed by unlinking its activities
Ribonuclease H2 (RNase H2) protects genome integrity by its dual roles of resolving transcription-related R-loops and ribonucleotides incorporated in DNA during replication. To unlink these two functions, we generated a Saccharomyces cerevisiae RNase H2 mutant that can resolve R-loops but cannot cle...
Autores principales: | Chon, Hyongi, Sparks, Justin L., Rychlik, Monika, Nowotny, Marcin, Burgers, Peter M., Crouch, Robert J., Cerritelli, Susana M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597693/ https://www.ncbi.nlm.nih.gov/pubmed/23355612 http://dx.doi.org/10.1093/nar/gkt027 |
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