MRX protects fork integrity at protein–DNA barriers, and its absence causes checkpoint activation dependent on chromatin context

To address how eukaryotic replication forks respond to fork stalling caused by strong non-covalent protein–DNA barriers, we engineered the controllable Fob-block system in Saccharomyces cerevisiae. This system allows us to strongly induce and control replication fork barriers (RFB) at their natural...

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Detalles Bibliográficos
Autores principales: Bentsen, Iben B., Nielsen, Ida, Lisby, Michael, Nielsen, Helena B., Gupta, Souvik Sen, Mundbjerg, Kamilla, Andersen, Anni H., Bjergbaek, Lotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597703/
https://www.ncbi.nlm.nih.gov/pubmed/23376930
http://dx.doi.org/10.1093/nar/gkt051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597703/
https://www.ncbi.nlm.nih.gov/pubmed/23376930
http://dx.doi.org/10.1093/nar/gkt051

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