Cargando…

Beta-Elemene Blocks Epithelial-Mesenchymal Transition in Human Breast Cancer Cell Line MCF-7 through Smad3-Mediated Down-Regulation of Nuclear Transcription Factors

Epithelial-mesenchymal transition (EMT) is the first step required for breast cancer to initiate metastasis. However, the potential of drugs to block and reverse the EMT process are not well explored. In the present study, we investigated the inhibitory effect of beta-elemene (ELE), an active compon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xian, Li, Yinghua, Zhang, Yang, Song, Jincheng, Wang, Qimin, Zheng, Luping, Liu, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597725/ https://www.ncbi.nlm.nih.gov/pubmed/23516540 http://dx.doi.org/10.1371/journal.pone.0058719

Ejemplares similares

Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
por: Pan, Yanhong, et al.
Publicado: (2019)

Renewable Beta‐Elemene Based Cyclic Carbonates for the Preparation of Oligo(hydroxyurethane)s
por: Maquilón, Cristina, et al.
Publicado: (2022)

Elémens de Chimie
Publicado: (1836)

Thalidomide Inhibits TGF-β1-induced Epithelial to Mesenchymal Transition in Alveolar Epithelial Cells via Smad-Dependent and Smad-Independent Signaling Pathways
por: Zhou, Xian-Long, et al.
Publicado: (2017)

microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway
por: Qiao, Pengfei, et al.
Publicado: (2015)

Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways
por: Park, Ji-Hyun, et al.
Publicado: (2017)

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation
por: Chen, Peng, et al.
Publicado: (2020)

Élemens de pathologie chirurgicale

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy
por: Zhai, Bingtao, et al.
Publicado: (2018)

miR-155 promotes proliferation and epithelial-mesenchymal transition of MCF-7 cells
por: Liu, Xiaoyan, et al.
Publicado: (2021)

Reversion of malignant phenotypes of human glioblastoma cells by β-elemene through β-catenin-mediated regulation of stemness-, differentiation- and epithelial-to-mesenchymal transition-related molecules
por: Zhu, Tingzhun, et al.
Publicado: (2015)

Resveratrol Suppresses Epithelial-Mesenchymal Transition in GBM by Regulating Smad-Dependent Signaling
por: Song, Yang, et al.
Publicado: (2019)

SMAD4 mutations do not preclude epithelial–mesenchymal transition in colorectal cancer
por: Frey, Patrick, et al.
Publicado: (2021)

Metadherin Promotes Malignant Phenotypes And Induces Beta-Catenin Nuclear Translocation And Epithelial–Mesenchymal Transition In Gastric Cancer
por: Feng, Di, et al.
Publicado: (2019)

Human adipose-derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial-mesenchymal transition by cross interacting with the TGF-β/Smad and PI3K/AKT signaling pathways
por: Wu, Simeng, et al.
Publicado: (2019)

CD82 attenuates TGF-β1-mediated epithelial-mesenchymal transition by blocking smad-dependent signaling in ARPE-19 cells
por: Lee, Hyesook, et al.
Publicado: (2022)

Curcumin for the Prevention of Epithelial-Mesenchymal Transition in Endoxifen-Treated MCF-7 Breast Cancer Cells
por: Paramita, P, et al.
Publicado: (2018)

CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC
por: Li, Hongyi, et al.
Publicado: (2022)

β-elemene combined with temozolomide in treatment of brain glioma
por: Zhang, Xiaomin, et al.
Publicado: (2021)

Notch prevents transforming growth factor-beta-assisted epithelial–mesenchymal transition in cultured limbal progenitor cells through the induction of Smad7
por: Tsai, Tung-Han, et al.
Publicado: (2014)

Trichostatin A reverses epithelial-mesenchymal transition and attenuates invasion and migration in MCF-7 breast cancer cells
por: Wang, Xiaoxiong, et al.
Publicado: (2020)

Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression
por: Cai, Hu, et al.
Publicado: (2021)

Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial-mesenchymal transition
por: Lin, Zhenlv, et al.
Publicado: (2019)

Role of Smad3 signaling in the epithelial-mesenchymal transition of the lens epithelium following injury
por: Meng, Fanlan, et al.
Publicado: (2018)

β-Elemene inhibits the proliferation of primary human airway granulation fibroblasts by down-regulating canonical Wnt/β-catenin pathway
por: Xue, Cheng, et al.
Publicado: (2018)

Beta-elemene inhibits differentiated thyroid carcinoma metastasis by reducing cellular proliferation, metabolism and invasion ability
por: Zhao, Lei, et al.
Publicado: (2020)

Down-Regulated CMTM2 Promotes Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
por: Zhang, Shidong, et al.
Publicado: (2020)

circSMAD2 inhibits the epithelial–mesenchymal transition by targeting miR-629 in hepatocellular carcinoma
por: Zhang, Xianwei, et al.
Publicado: (2018)

Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-α
por: Câmara, Joana, et al.
Publicado: (2010)

β-Elemene Synergizes With Gefitinib to Inhibit Stem-Like Phenotypes and Progression of Lung Cancer via Down-Regulating EZH2
por: Cheng, Haibo, et al.
Publicado: (2018)

The reversal of antineoplastic drug resistance in cancer cells by β-elemene
por: Zhang, Guan-Nan, et al.
Publicado: (2015)

Repression of Smad3 by silencing Robo1 attenuates epithelial-mesenchymal transition in tracheobronchial stenosis
por: He, Chunyan, et al.
Publicado: (2023)

Down‐regulated HDAC3 elevates microRNA‐495‐3p to restrain epithelial‐mesenchymal transition and oncogenicity of melanoma cells via reducing TRAF5
por: Ma, Yanbo, et al.
Publicado: (2020)

Requirement of Podocalyxin in TGF-Beta Induced Epithelial Mesenchymal Transition
por: Meng, Xiaobo, et al.
Publicado: (2011)

MicroRNA-23a regulates epithelial-to-mesenchymal transition in endometrial endometrioid adenocarcinoma by targeting SMAD3
por: Liu, Ping, et al.
Publicado: (2016)

Effects of bisphenol compounds on the growth and epithelial mesenchymal transition of MCF-7 CV human breast cancer cells
por: Kim, Ji-Youn, et al.
Publicado: (2017)

Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation
por: Zhao, Fan, et al.
Publicado: (2020)

NGAL protects in nasopharyngeal carcinoma by inducing apoptosis and blocking epithelial-mesenchymal transition
por: Guo, Ying, et al.
Publicado: (2020)

CRTC2 activates the epithelial–mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway
por: Li, Yujie, et al.
Publicado: (2023)

MiR-21-5p in Macrophage-Derived Exosomes Targets Smad7 to Promote Epithelial Mesenchymal Transition of Airway Epithelial Cells
por: Li, Xiang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gd1eb2jhvkvtsi6nnp2nvokkhm