Regulation of Argonaute Slicer Activity by Guide RNA 3′ End Interactions with the N-terminal Lobe

Structural studies indicate that binding of both the guide RNA (siRNA and miRNA) and the target mRNA trigger substantial conformational changes in the Argonaute proteins. Here we explore the role of the N-terminal lobe (and its PAZ domain) in these conformational changes using biochemical and cell c...

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Detalles Bibliográficos
Autores principales: Hur, Junho K., Zinchenko, Michelle K., Djuranovic, Sergej, Green, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597821/
https://www.ncbi.nlm.nih.gov/pubmed/23329841
http://dx.doi.org/10.1074/jbc.M112.441030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597821/
https://www.ncbi.nlm.nih.gov/pubmed/23329841
http://dx.doi.org/10.1074/jbc.M112.441030

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