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A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia
RAD51 recombinase activity plays a critical role for cancer cell proliferation and survival, and often contributes to drug-resistance. Abnormally elevated RAD51 function and hyperactive homologous recombination (HR) rates have been found in a panel of cancers, including breast cancer and chronic mye...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598077/ https://www.ncbi.nlm.nih.gov/pubmed/23341130 http://dx.doi.org/10.1002/emmm.201201760 |