A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia

RAD51 recombinase activity plays a critical role for cancer cell proliferation and survival, and often contributes to drug-resistance. Abnormally elevated RAD51 function and hyperactive homologous recombination (HR) rates have been found in a panel of cancers, including breast cancer and chronic mye...

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Detalles Bibliográficos
Autores principales: Zhu, Jiewen, Zhou, Longen, Wu, Guikai, Konig, Heiko, Lin, Xiaoqin, Li, Guideng, Qiu, Xiao-Long, Chen, Chi-Fen, Hu, Chun-Mei, Goldblatt, Erin, Bhatia, Ravi, Chamberlin, A Richard, Chen, Phang-Lang, Lee, Wen-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598077/
https://www.ncbi.nlm.nih.gov/pubmed/23341130
http://dx.doi.org/10.1002/emmm.201201760

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