3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

BACKGROUND: The spatial organization of the genome is being evaluated as a novel indicator of toxicity in conjunction with drug-induced global DNA hypomethylation and concurrent chromatin reorganization. 3D quantitative DNA methylation imaging (3D-qDMI) was applied as a cell-by-cell high-throughput...

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Detalles Bibliográficos
Autores principales: Gertych, Arkadiusz, Oh, Jin Ho, Wawrowsky, Kolja A, Weisenberger, Daniel J, Tajbakhsh, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598242/
https://www.ncbi.nlm.nih.gov/pubmed/23394161
http://dx.doi.org/10.1186/2050-6511-14-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598242/
https://www.ncbi.nlm.nih.gov/pubmed/23394161
http://dx.doi.org/10.1186/2050-6511-14-11

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