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3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models
BACKGROUND: The spatial organization of the genome is being evaluated as a novel indicator of toxicity in conjunction with drug-induced global DNA hypomethylation and concurrent chromatin reorganization. 3D quantitative DNA methylation imaging (3D-qDMI) was applied as a cell-by-cell high-throughput...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598242/ https://www.ncbi.nlm.nih.gov/pubmed/23394161 http://dx.doi.org/10.1186/2050-6511-14-11 |