Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in Rheumatoid Arthritis

Epigenetic mechanisms integrate genetic and environmental causes of disease. Comprehensive genome-wide analyses of epigenetic modifications have not demonstrated robust association with common diseases. Using Illumina HumanMethylation450 arrays on 354 ACPA positive rheumatoid arthritis (RA) cases an...

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Detalles Bibliográficos
Autores principales: Liu, Yun, Aryee, Martin J., Padyukov, Leonid, Fallin, M. Daniele, Hesselberg, Espen, Runarsson, Arni, Reinius, Lovisa, Acevedo, Nathalie, Taub, Margaret, Ronninger, Marcus, Shchetynsky, Klementy, Scheynius, Annika, Kere, Juha, Alfredsson, Lars, Klareskog, Lars, Ekström, Tomas J., Feinberg, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598632/
https://www.ncbi.nlm.nih.gov/pubmed/23334450
http://dx.doi.org/10.1038/nbt.2487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598632/
https://www.ncbi.nlm.nih.gov/pubmed/23334450
http://dx.doi.org/10.1038/nbt.2487

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