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Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury

BACKGROUND: Individuals with deficiencies of pulmonary surfactant protein C (SP-C) develop interstitial lung disease (ILD) that is exacerbated by viral infections including respiratory syncytial virus (RSV). SP-C gene targeted mice (Sftpc -/-) lack SP-C, develop an ILD-like disease and are susceptib...

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Detalles Bibliográficos
Autores principales: Glasser, Stephan W, Senft, Albert P, Maxfield, Melissa D, Ruetschilling, Teah L, Baatz, John E, Page, Kristen, Korfhagen, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598668/
https://www.ncbi.nlm.nih.gov/pubmed/23399055
http://dx.doi.org/10.1186/1465-9921-14-19