Fibroblast Growth Factor 2 Induces E-Cadherin Down-Regulation via PI3K/Akt/mTOR and MAPK/ERK Signaling in Ovarian Cancer Cells

Fibroblast growth factor 2 (FGF2) is produced by ovarian cancer cells and it has been suggested to play an important role in tumor progression. In this study, we report that FGF2 treatment down-regulated E-cadherin by up-regulating its transcriptional repressors, Slug and ZEB1, in human ovarian canc...

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Detalles Bibliográficos
Autores principales: Lau, Man-Tat, So, Wai-Kin, Leung, Peter C. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598697/
https://www.ncbi.nlm.nih.gov/pubmed/23554977
http://dx.doi.org/10.1371/journal.pone.0059083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598697/
https://www.ncbi.nlm.nih.gov/pubmed/23554977
http://dx.doi.org/10.1371/journal.pone.0059083

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