Combined RNAi-Mediated Suppression of Rictor and EGFR Resulted in Complete Tumor Regression in an Orthotopic Glioblastoma Tumor Model

The PI3K/AKT/mTOR pathway is commonly over activated in glioblastoma (GBM), and Rictor was shown to be an important regulator downstream of this pathway. EGFR overexpression is also frequently found in GBM tumors, and both EGFR and Rictor are associated with increased proliferation, invasion, metast...

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Detalles Bibliográficos
Autores principales: Verreault, Maite, Weppler, Sherry A., Stegeman, Amelia, Warburton, Corinna, Strutt, Dita, Masin, Dana, Bally, Marcel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598699/
https://www.ncbi.nlm.nih.gov/pubmed/23555046
http://dx.doi.org/10.1371/journal.pone.0059597

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598699/
https://www.ncbi.nlm.nih.gov/pubmed/23555046
http://dx.doi.org/10.1371/journal.pone.0059597

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