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Knockdown of HPRT for Selection of Genetically Modified Human Hematopoietic Progenitor Cells
The inability to obtain sufficient numbers of transduced cells remains a limitation in gene therapy. One strategy to address this limitation is in vivo pharmacologic selection of transduced cells. We have previously shown that knockdown of HPRT using lentiviral delivered shRNA facilitates efficient...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598703/ https://www.ncbi.nlm.nih.gov/pubmed/23555045 http://dx.doi.org/10.1371/journal.pone.0059594 |