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Knockdown of HPRT for Selection of Genetically Modified Human Hematopoietic Progenitor Cells

The inability to obtain sufficient numbers of transduced cells remains a limitation in gene therapy. One strategy to address this limitation is in vivo pharmacologic selection of transduced cells. We have previously shown that knockdown of HPRT using lentiviral delivered shRNA facilitates efficient...

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Detalles Bibliográficos
Autores principales:	Choudhary, Rashmi, Baturin, Dmitry, Fosmire, Susan, Freed, Brian, Porter, Christopher C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598703/ https://www.ncbi.nlm.nih.gov/pubmed/23555045 http://dx.doi.org/10.1371/journal.pone.0059594

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