Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

BACKGROUND: Because Plasmodium falciparum displays increase tolerance against the recommended artemisinin combination therapies (ACT), new classes of anti-malarial drugs are urgently required. Previously synthesized artemisinin-aminoquinoline hybrids were evaluated to ascertain whether the potent lo...

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Detalles Bibliográficos
Autores principales: Lombard, Marli C, N’Da, David D, Tran Van Ba, Christophe, Wein, Sharon, Norman, Jennifer, Wiesner, Lubbe, Vial, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598976/
https://www.ncbi.nlm.nih.gov/pubmed/23433124
http://dx.doi.org/10.1186/1475-2875-12-71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598976/
https://www.ncbi.nlm.nih.gov/pubmed/23433124
http://dx.doi.org/10.1186/1475-2875-12-71

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