Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study

BACKGROUND: There are two main reasons for drug withdrawals at the various levels of the development path – hepatic and cardiac toxicity. The latter one is mainly connected with the proarrhythmic potency and according to the present practice is supposed to be recognized at the pre-clinical (in vitro...

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Detalles Bibliográficos
Autores principales: Fijorek, Kamil, Patel, Nikunjkumar, Klima, Łukasz, Stolarz-Skrzypek, Katarzyna, Kawecka-Jaszcz, Kalina, Polak, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598978/
https://www.ncbi.nlm.nih.gov/pubmed/23394137
http://dx.doi.org/10.1186/1742-4682-10-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598978/
https://www.ncbi.nlm.nih.gov/pubmed/23394137
http://dx.doi.org/10.1186/1742-4682-10-7

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