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Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study
BACKGROUND: There are two main reasons for drug withdrawals at the various levels of the development path – hepatic and cardiac toxicity. The latter one is mainly connected with the proarrhythmic potency and according to the present practice is supposed to be recognized at the pre-clinical (in vitro...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598978/ https://www.ncbi.nlm.nih.gov/pubmed/23394137 http://dx.doi.org/10.1186/1742-4682-10-7 |