Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB

BACKGROUND: Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients, accelerating the progression of CKD. In CKD rat kidney, the expressions of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and its related genes are downregulated. AST-120, an oral s...

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Detalles Bibliográficos
Autores principales: Bolati, Dilinaer, Shimizu, Hidehisa, Yisireyili, Maimaiti, Nishijima, Fuyuhiko, Niwa, Toshimitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599003/
https://www.ncbi.nlm.nih.gov/pubmed/23496811
http://dx.doi.org/10.1186/1471-2369-14-56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599003/
https://www.ncbi.nlm.nih.gov/pubmed/23496811
http://dx.doi.org/10.1186/1471-2369-14-56

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