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Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB

BACKGROUND: Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients, accelerating the progression of CKD. In CKD rat kidney, the expressions of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and its related genes are downregulated. AST-120, an oral s...

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Detalles Bibliográficos
Autores principales:	Bolati, Dilinaer, Shimizu, Hidehisa, Yisireyili, Maimaiti, Nishijima, Fuyuhiko, Niwa, Toshimitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599003/ https://www.ncbi.nlm.nih.gov/pubmed/23496811 http://dx.doi.org/10.1186/1471-2369-14-56

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