SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disorder with aberrant regulation of a variety of signal pathways. Therefore, simultaneous targeting of two or even more deregulated signal transduction pathways is needed to overcome drug resistance. Previously, it was reported that SNS-03...

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Detalles Bibliográficos
Autores principales: Meng, Haitao, Jin, Yingming, Liu, Hui, You, Liangshun, Yang, Chunmei, Yang, Xue, Qian, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599109/
https://www.ncbi.nlm.nih.gov/pubmed/23415012
http://dx.doi.org/10.1186/1756-8722-6-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599109/
https://www.ncbi.nlm.nih.gov/pubmed/23415012
http://dx.doi.org/10.1186/1756-8722-6-18

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