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SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disorder with aberrant regulation of a variety of signal pathways. Therefore, simultaneous targeting of two or even more deregulated signal transduction pathways is needed to overcome drug resistance. Previously, it was reported that SNS-03...

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Detalles Bibliográficos
Autores principales:	Meng, Haitao, Jin, Yingming, Liu, Hui, You, Liangshun, Yang, Chunmei, Yang, Xue, Qian, Wenbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599109/ https://www.ncbi.nlm.nih.gov/pubmed/23415012 http://dx.doi.org/10.1186/1756-8722-6-18

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