Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

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BACKGROUND: In 2011, Royston et al. described technical details of a two-arm, multi-stage (TAMS) design. The design enables a trial to be stopped part-way through recruitment if the accumulating data suggests a lack of benefit of the experimental arm. Such interim decisions can be made using data on...

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Detalles Bibliográficos
Autores principales: Choodari-Oskooei, Babak, Parmar, Mahesh KB, Royston, Patrick, Bowden, Jack
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599134/
https://www.ncbi.nlm.nih.gov/pubmed/23343147
http://dx.doi.org/10.1186/1745-6215-14-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599134/
https://www.ncbi.nlm.nih.gov/pubmed/23343147
http://dx.doi.org/10.1186/1745-6215-14-23

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