Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus

BACKGROUND: Fragile X syndrome (FXS) is a common form of inherited intellectual disability caused by an expansion of CGG repeats located in the 5(′) untranslated region (UTR) of the FMR1 gene, which leads to hypermethylation and silencing of this locus. Although a dramatic increase in DNA methylatio...

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Detalles Bibliográficos
Autores principales: Alisch, Reid S, Wang, Tao, Chopra, Pankaj, Visootsak, Jeannie, Conneely, Karen N, Warren, Stephen T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599197/
https://www.ncbi.nlm.nih.gov/pubmed/23356558
http://dx.doi.org/10.1186/1471-2350-14-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599197/
https://www.ncbi.nlm.nih.gov/pubmed/23356558
http://dx.doi.org/10.1186/1471-2350-14-18

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