TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

BACKGROUND: Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1 infectivity. Some investigators have reported that TNPO3 promotes HIV-1 nuclear import, a...

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Detalles Bibliográficos
Autores principales: De Iaco, Alberto, Santoni, Federico, Vannier, Anne, Guipponi, Michel, Antonarakis, Stylianos, Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599327/
https://www.ncbi.nlm.nih.gov/pubmed/23414560
http://dx.doi.org/10.1186/1742-4690-10-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599327/
https://www.ncbi.nlm.nih.gov/pubmed/23414560
http://dx.doi.org/10.1186/1742-4690-10-20

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