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TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

BACKGROUND: Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1 infectivity. Some investigators have reported that TNPO3 promotes HIV-1 nuclear import, a...

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Detalles Bibliográficos
Autores principales:	De Iaco, Alberto, Santoni, Federico, Vannier, Anne, Guipponi, Michel, Antonarakis, Stylianos, Luban, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599327/ https://www.ncbi.nlm.nih.gov/pubmed/23414560 http://dx.doi.org/10.1186/1742-4690-10-20

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