A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Sequential cleavage of miRNA precursors results in a ~22 nucleotide duplex of which one strand, the mature miRNA, is typically loaded into the RNA-induced silencing complex (RISC) while the...

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Detalles Bibliográficos
Autores principales: Ohanian, Monique, Humphreys, David T, Anderson, Elizabeth, Preiss, Thomas, Fatkin, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599331/
https://www.ncbi.nlm.nih.gov/pubmed/23497314
http://dx.doi.org/10.1186/1471-2156-14-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599331/
https://www.ncbi.nlm.nih.gov/pubmed/23497314
http://dx.doi.org/10.1186/1471-2156-14-18

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