The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals

BACKGROUND: The presence of a vpx gene distinguishes HIV-2 from HIV-1, the main causative agent of AIDS. Vpx degrades the restriction factor SAMHD1 to boost HIV-2 infection of macrophages and dendritic cells and it has been suggested that the activation of antiviral innate immune responses after Vpx...

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Detalles Bibliográficos
Autores principales: Yu, Hangxing, Usmani, Shariq M, Borch, Alexandra, Krämer, Julia, Stürzel, Christina M, Khalid, Mohammad, Li, Xuehua, Krnavek, Daniela, van der Ende, Marchina E, Osterhaus, Albert D, Gruters, Rob A, Kirchhoff, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599662/
https://www.ncbi.nlm.nih.gov/pubmed/23497283
http://dx.doi.org/10.1186/1742-4690-10-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599662/
https://www.ncbi.nlm.nih.gov/pubmed/23497283
http://dx.doi.org/10.1186/1742-4690-10-27

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