Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy

IL-4 plays critical roles in allergic disorders, including food hypersensitivity. The direct effects of the cytokine on the survival and function of mast cells, the key effectors of food anaphylaxis, have not been established. In this study we demonstrate that IL-4 induces a marked intestinal mastoc...

Descripción completa

Detalles Bibliográficos
Autores principales: Burton, Oliver T, Darling, Alanna R, Zhou, Joseph S, Noval-Rivas, Magali, Jones, Tatiana G, Gurish, Michael F, Chatila, Talal A, Oettgen, Hans C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600405/
https://www.ncbi.nlm.nih.gov/pubmed/23149659
http://dx.doi.org/10.1038/mi.2012.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600405/
https://www.ncbi.nlm.nih.gov/pubmed/23149659
http://dx.doi.org/10.1038/mi.2012.112

Ejemplares similares