Effect of Ritonavir on (99m)Technetium–Mebrofenin Disposition in Humans: A Semi-PBPK Modeling and In Vitro Approach to Predict Transporter-Mediated DDIs

A semiphysiologically based pharmacokinetic (semi-PBPK) model was developed to describe a unique blood, liver, and bile clinical data set for the hepatobiliary imaging agent (99m)Technetium–mebrofenin ((99m)Tc–mebrofenin), and to simulate sites/mechanisms of a (99m)Tc–mebrofenin–ritonavir drug–drug...

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Detalles Bibliográficos
Autores principales: Pfeifer, N D, Goss, S L, Swift, B, Ghibellini, G, Ivanovic, M, Heizer, W D, Gangarosa, L M, Brouwer, K L R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600725/
https://www.ncbi.nlm.nih.gov/pubmed/23887590
http://dx.doi.org/10.1038/psp.2012.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600725/
https://www.ncbi.nlm.nih.gov/pubmed/23887590
http://dx.doi.org/10.1038/psp.2012.21

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