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Has the Time Come for Predictive Computer Modeling in CNS Drug Discovery and Development?
We discuss whether a new paradigm, quantitative systems pharmacology (QSP), based on computational neuroscience modeling combined with proper drug target engagement and pharmacology, human pathology, imaging studies, and calibration and validation using clinical studies in human subjects might impro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600733/ https://www.ncbi.nlm.nih.gov/pubmed/23835798 http://dx.doi.org/10.1038/psp.2012.17 |