Vertical Integration of Pharmacogenetics in Population PK/PD Modeling: A Novel Information Theoretic Method

To critically evaluate an information-theoretic method for identifying gene–environmental interactions (GEI) associated with pharmacokinetic (PK), pharmacodynamic (PD), and clinical outcomes from genome-wide pharmacogenetic data. Our approach, which is built on the K-way interaction information (KWI...

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Detalles Bibliográficos
Autores principales: Knights, J, Chanda, P, Sato, Y, Kaniwa, N, Saito, Y, Ueno, H, Zhang, A, Ramanathan, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600754/
http://dx.doi.org/10.1038/psp.2012.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600754/
http://dx.doi.org/10.1038/psp.2012.25

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