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Vertical Integration of Pharmacogenetics in Population PK/PD Modeling: A Novel Information Theoretic Method
To critically evaluate an information-theoretic method for identifying gene–environmental interactions (GEI) associated with pharmacokinetic (PK), pharmacodynamic (PD), and clinical outcomes from genome-wide pharmacogenetic data. Our approach, which is built on the K-way interaction information (KWI...
Autores principales: | Knights, J, Chanda, P, Sato, Y, Kaniwa, N, Saito, Y, Ueno, H, Zhang, A, Ramanathan, M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600754/ http://dx.doi.org/10.1038/psp.2012.25 |
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