IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

Here, we show that interleukin-1 (IL-1) enhances antigen-driven CD8 T cell responses. When administered to recipients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 results in an increase in the numbers of wild-type but not IL1R1(−/−) OT-I cells, particu...

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Detalles Bibliográficos
Autores principales: Ben-Sasson, Shlomo Z., Hogg, Alison, Hu-Li, Jane, Wingfield, Paul, Chen, Xi, Crank, Michelle, Caucheteux, Stephane, Ratner-Hurevich, Maya, Berzofsky, Jay A., Nir-Paz, Ran, Paul, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600912/
https://www.ncbi.nlm.nih.gov/pubmed/23460726
http://dx.doi.org/10.1084/jem.20122006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600912/
https://www.ncbi.nlm.nih.gov/pubmed/23460726
http://dx.doi.org/10.1084/jem.20122006

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