Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes

Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to imm...

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Autores principales: Mailloux, Adam W., Epling-Burnette, Pearlie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601152/
https://www.ncbi.nlm.nih.gov/pubmed/23524348
http://dx.doi.org/10.4161/onci.22654
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author Mailloux, Adam W.
Epling-Burnette, Pearlie K.
author_facet Mailloux, Adam W.
Epling-Burnette, Pearlie K.
author_sort Mailloux, Adam W.
collection PubMed
description Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognostic indicator in MDS.
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spelling pubmed-36011522013-03-22 Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes Mailloux, Adam W. Epling-Burnette, Pearlie K. Oncoimmunology Author's View Myleodysplastic syndromes (MDS) are pre-malignant hematopoietic diseases that can progress to acute myeloid leukemia (AML) progression in conjunction with changes in immune function. In this model of leukemia evolution, the expansion of immunosuppressive regulatory T cells (Tregs) contributes to immune escape. Here, we discuss the importance of Treg-memory phenotype switching as a poor prognostic indicator in MDS. Landes Bioscience 2013-02-01 /pmc/articles/PMC3601152/ /pubmed/23524348 http://dx.doi.org/10.4161/onci.22654 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Mailloux, Adam W.
Epling-Burnette, Pearlie K.
Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
title Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
title_full Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
title_fullStr Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
title_full_unstemmed Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
title_short Effector memory regulatory T-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
title_sort effector memory regulatory t-cell expansion marks a pivotal point of immune escape in myelodysplastic syndromes
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601152/
https://www.ncbi.nlm.nih.gov/pubmed/23524348
http://dx.doi.org/10.4161/onci.22654
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