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Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer

The blockade of the PD-1 pathway can increase the production of interferon γ by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy t...

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Detalles Bibliográficos
Autores principales: Peng, Weiyi, Lizée, Gregory, Hwu, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601154/
https://www.ncbi.nlm.nih.gov/pubmed/23524510
http://dx.doi.org/10.4161/onci.22691
Descripción
Sumario:The blockade of the PD-1 pathway can increase the production of interferon γ by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy to achieve superior antitumor responses.