How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization

The polarization of T(H)1 or T(H)2 responses by dendritic cells (DCs) requires distinct maturation conditions. Our data indicate that quantitative differences in DC maturation dictate a T(H1) or T(H)2-cell polarization outcome. We discuss how chromatin remodeling at DC loci coding for pro-inflammato...

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Detalles Bibliográficos
Autor principal: Lutz, Manfred B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601159/
https://www.ncbi.nlm.nih.gov/pubmed/23525517
http://dx.doi.org/10.4161/onci.22796
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author Lutz, Manfred B.
author_facet Lutz, Manfred B.
author_sort Lutz, Manfred B.
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description The polarization of T(H)1 or T(H)2 responses by dendritic cells (DCs) requires distinct maturation conditions. Our data indicate that quantitative differences in DC maturation dictate a T(H1) or T(H)2-cell polarization outcome. We discuss how chromatin remodeling at DC loci coding for pro-inflammatory vs. polarizing cytokines may explain differential T(H)-cell polarization.
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spelling pubmed-36011592013-03-22 How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization Lutz, Manfred B. Oncoimmunology Author's View The polarization of T(H)1 or T(H)2 responses by dendritic cells (DCs) requires distinct maturation conditions. Our data indicate that quantitative differences in DC maturation dictate a T(H1) or T(H)2-cell polarization outcome. We discuss how chromatin remodeling at DC loci coding for pro-inflammatory vs. polarizing cytokines may explain differential T(H)-cell polarization. Landes Bioscience 2013-02-01 /pmc/articles/PMC3601159/ /pubmed/23525517 http://dx.doi.org/10.4161/onci.22796 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Lutz, Manfred B.
How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization
title How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization
title_full How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization
title_fullStr How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization
title_full_unstemmed How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization
title_short How quantitative differences in dendritic cell maturation can direct T(H)1/T(H)2-cell polarization
title_sort how quantitative differences in dendritic cell maturation can direct t(h)1/t(h)2-cell polarization
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601159/
https://www.ncbi.nlm.nih.gov/pubmed/23525517
http://dx.doi.org/10.4161/onci.22796
work_keys_str_mv AT lutzmanfredb howquantitativedifferencesindendriticcellmaturationcandirectth1th2cellpolarization

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