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Engineering effective T-cell based antitumor immunity
The adoptive transfer of synthetic siRNA-mediated cblb-depleted autologous CD8(+) T cells acts as a potent adjuvant for dendritic cell (DC) vaccination and provides a significant therapeutic benefit. Our proof-of-concept study validates the strategy of inhibiting CBLB as a rational approach to augme...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601162/ https://www.ncbi.nlm.nih.gov/pubmed/23525844 http://dx.doi.org/10.4161/onci.22893 |