Cargando…

Engineering effective T-cell based antitumor immunity

The adoptive transfer of synthetic siRNA-mediated cblb-depleted autologous CD8(+) T cells acts as a potent adjuvant for dendritic cell (DC) vaccination and provides a significant therapeutic benefit. Our proof-of-concept study validates the strategy of inhibiting CBLB as a rational approach to augme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gruber, Thomas, Hinterleitner, Reinhard, Pfeifhofer-Obermair, Christa, Wolf, Dominik, Baier, Gottfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601162/ https://www.ncbi.nlm.nih.gov/pubmed/23525844 http://dx.doi.org/10.4161/onci.22893

Ejemplares similares

PKCθ is necessary for efficient activation of NFκB, NFAT, and AP-1 during positive selection of thymocytes
por: Gruber, Thomas, et al.
Publicado: (2010)

Adoptive Transfer of siRNA Cblb-Silenced CD8(+) T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model
por: Hinterleitner, Reinhard, et al.
Publicado: (2012)

The Kinase PKCα Selectively Upregulates Interleukin-17A during Th17 Cell Immune Responses
por: Meisel, Marlies, et al.
Publicado: (2013)

Involvement of distinct PKC gene products in T cell functions
por: Pfeifhofer-Obermair, Christa, et al.
Publicado: (2012)

Retinoic acid on stage in antitumor immunity
por: Guo, Yanxia, et al.
Publicado: (2013)

Polyamine blockade promotes antitumor immunity
por: Hayes, Candace S, et al.
Publicado: (2014)

Targeting coagulation to unlock antitumor immunity?
por: Galmiche, Antoine, et al.
Publicado: (2022)

Activation of systemic antitumor immunity via TRAIL-induced apoptosis
por: James, Britnie R., et al.
Publicado: (2012)

Catechins and antitumor immunity: Not MDSC’s cup of tea
por: Santilli, Giorgia, et al.
Publicado: (2013)

Crucial role of inflammatory monocytes in antitumor immunity
por: Pommier, Arnaud, et al.
Publicado: (2013)

Tertiary lymphoid structures in human lung cancers, a new driver of antitumor immune responses
por: Goc, Jérémy, et al.
Publicado: (2014)

Targeting human CD27 with an agonist antibody stimulates T-cell activation and antitumor immunity
por: Thomas, Lawrence J, et al.
Publicado: (2014)

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance
por: Hermann-Kleiter, Natascha, et al.
Publicado: (2015)

Potentiating antitumor immunity with αGC-loaded exosomes
por: Gehrmann, Ulf, et al.
Publicado: (2013)

Monocyte-derived dendritic cells: Emerging players in the antitumor immune response
por: Kuhn, Sabine, et al.
Publicado: (2013)

High endothelial venules: Help or hindrance in the quest for antitumor immunity?
por: Gallimore, Awen, et al.
Publicado: (2013)

Antibody-based depletion of Foxp3+ T cells potentiates antitumor immune memory stimulated by mTOR inhibition
por: Kim, Hyung L
Publicado: (2014)

A Janus-faced role of the unfolded protein response in antitumor immunity
por: Mahadevan, Navin R., et al.
Publicado: (2013)

B7-H4 is a positive regulator of antitumor immunity
por: Rahbar, Ramtin, et al.
Publicado: (2015)

A clinically useful approach to enhance immunological memory and antitumor immunity
por: Berezhnoy, Alex, et al.
Publicado: (2014)

RON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses
por: Eyob, Henok, et al.
Publicado: (2013)

Is preexisting antitumor CD4 T cell response indispensable for the chemotherapy induced immune regression of cancer?
por: Godet, Yann, et al.
Publicado: (2012)

Engineering Grp170-based immune modulators for cancer immunotherapy
por: Yu, Xiaofei, et al.
Publicado: (2013)

The short and sweet of T-cell therapy: Restraining glycolysis enhances the formation of immunological memory and antitumor immune responses
por: Sukumar, Madhusudhanan, et al.
Publicado: (2014)

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies
por: Verbrugge, Inge, et al.
Publicado: (2012)

Licensing of γδT cells for professional antigen presentation: A new role for antibodies in regulation of antitumor immune responses
por: Anderson, John, et al.
Publicado: (2012)

New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity
por: Guéry, Leslie, et al.
Publicado: (2015)

Push and release: TLR9 activation plus STAT3 blockade for systemic antitumor immunity
por: Kortylewski, Marcin, et al.
Publicado: (2014)

Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses
por: Gujar, Shashi A, et al.
Publicado: (2014)

Extracellular vesicles released by ovarian carcinoma contain arginase 1 that mitigates antitumor immune response
por: Sosnowska, Anna, et al.
Publicado: (2019)

Synergistic antitumor effects of a TGFβ inhibitor and cyclophosphamide
por: Chen, Xin, et al.
Publicado: (2014)

PD-L1 expression and tumor-infiltrating lymphocytes: Revisiting the antitumor immune response potential in breast cancer
por: Schalper, Kurt A
Publicado: (2014)

A novel actor in antitumoral immunity: The thymus-specific serine protease TSSP/PRSS16 involved in CD4(+) T-cell maturation
por: Brisson, Lydie, et al.
Publicado: (2015)

Arming NK cells with enhanced antitumor activity: CARs and beyond
por: Oberoi, Pranav, et al.
Publicado: (2013)

Role of the complement system in NK cell-mediated antitumor T-cell responses
por: Janelle, Valérie, et al.
Publicado: (2014)

Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2
por: Rekers, Nicolle H, et al.
Publicado: (2015)

Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
por: Zhao, Jie, et al.
Publicado: (2014)

Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice
por: Pfeifhofer-Obermair, Christa, et al.
Publicado: (2016)

The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
por: Wong, Hing C, et al.
Publicado: (2013)

Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies
por: Abate-Daga, Daniel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_1pmmq55o6tppr8j9191380cgqa