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Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration

The molecular mechanism underlying the selective vulnerability of certain neuronal populations associated with neurodegenerative diseases remains poorly understood. Basal autophagy is important for maintaining axonal homeostasis and preventing neurodegeneration. In this paper, we demonstrate that mi...

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Detalles Bibliográficos
Autores principales: Zhao, Hongyu, Zhao, Yan G., Wang, Xingwei, Xu, Lanjun, Miao, Lin, Feng, Du, Chen, Quan, Kovács, Attila L., Fan, Dongsheng, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601354/
https://www.ncbi.nlm.nih.gov/pubmed/23479740
http://dx.doi.org/10.1083/jcb.201211014