Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a crucial anticancer barrier. DDR inactivation in these conditions promotes genome instability and tumor progression, but the underlying molecular mechanisms are elusive. We found that overexpression of both Cyclin E an...

Descripción completa

Detalles Bibliográficos
Autores principales: Neelsen, Kai J., Zanini, Isabella M.Y., Herrador, Raquel, Lopes, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601361/
https://www.ncbi.nlm.nih.gov/pubmed/23479741
http://dx.doi.org/10.1083/jcb.201212058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601361/
https://www.ncbi.nlm.nih.gov/pubmed/23479741
http://dx.doi.org/10.1083/jcb.201212058

Ejemplares similares