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pH-selective mutagenesis of protein–protein interfaces: In silico design of therapeutic antibodies with prolonged half-life
Understanding the effects of mutation on pH-dependent protein binding affinity is important in protein design, especially in the area of protein therapeutics. We propose a novel method for fast in silico mutagenesis of protein–protein complexes to calculate the effect of mutation as a function of pH...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601434/ https://www.ncbi.nlm.nih.gov/pubmed/23239118 http://dx.doi.org/10.1002/prot.24230 |