Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase

[Image: see text] N-Myristoyltransferase (NMT) is an attractive antiprotozoan drug target. A lead-hopping approach was utilized in the design and synthesis of novel benzo[b]thiophene-containing inhibitors of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) NMT. These inhibitors are selective aga...

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Detalles Bibliográficos
Autores principales: Rackham, Mark D., Brannigan, James A., Moss, David K., Yu, Zhiyong, Wilkinson, Anthony J., Holder, Anthony A., Tate, Edward W., Leatherbarrow, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601602/
https://www.ncbi.nlm.nih.gov/pubmed/23170970
http://dx.doi.org/10.1021/jm301474t

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601602/
https://www.ncbi.nlm.nih.gov/pubmed/23170970
http://dx.doi.org/10.1021/jm301474t

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