Molecular Modeling of Disease Causing Mutations in Domain C1 of cMyBP-C

Cardiac myosin binding protein-C (cMyBP-C) is a multi-domain (C0–C10) protein that regulates heart muscle contraction through interaction with myosin, actin and other sarcomeric proteins. Several mutations of this protein cause familial hypertrophic cardiomyopathy (HCM). Domain C1 of cMyBP-C plays a...

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Detalles Bibliográficos
Autores principales: Gajendrarao, Poornima, Krishnamoorthy, Navaneethakrishnan, Kassem, Heba Sh, Moharem-Elgamal, Sarah, Cecchi, Franco, Olivotto, Iacopo, Yacoub, Magdi H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602012/
https://www.ncbi.nlm.nih.gov/pubmed/23527136
http://dx.doi.org/10.1371/journal.pone.0059206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602012/
https://www.ncbi.nlm.nih.gov/pubmed/23527136
http://dx.doi.org/10.1371/journal.pone.0059206

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