The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

BACKGROUND: Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional i...

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Detalles Bibliográficos
Autores principales: Nielsen, Finn Thomsen, Jensen, Boye L, Hansen, Pernille BL, Marcussen, Niels, Bie, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602207/
https://www.ncbi.nlm.nih.gov/pubmed/23425330
http://dx.doi.org/10.1186/1471-2369-14-42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602207/
https://www.ncbi.nlm.nih.gov/pubmed/23425330
http://dx.doi.org/10.1186/1471-2369-14-42

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