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The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

BACKGROUND: Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional i...

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Detalles Bibliográficos
Autores principales:	Nielsen, Finn Thomsen, Jensen, Boye L, Hansen, Pernille BL, Marcussen, Niels, Bie, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602207/ https://www.ncbi.nlm.nih.gov/pubmed/23425330 http://dx.doi.org/10.1186/1471-2369-14-42

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