Cellular Source-Specific Effects of Apolipoprotein (Apo) E4 on Dendrite Arborization and Dendritic Spine Development

Apolipoprotein (apo) E4 is the leading genetic risk factor for Alzheimer’s disease (AD), and it has a gene dose-dependent effect on the risk and age of onset of AD. Although apoE4 is primarily produced by astrocytes in the brain, neurons can also produce apoE4 under stress conditions. ApoE4 is known...

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Detalles Bibliográficos
Autores principales: Jain, Sachi, Yoon, Seo Yeon, Leung, Laura, Knoferle, Johanna, Huang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602301/
https://www.ncbi.nlm.nih.gov/pubmed/23527202
http://dx.doi.org/10.1371/journal.pone.0059478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602301/
https://www.ncbi.nlm.nih.gov/pubmed/23527202
http://dx.doi.org/10.1371/journal.pone.0059478

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